Title Glioblastoma Segmentation: Comparison of Three Different Software Packages
Domain: Professional and Applied sciences, Field: Healthcare science, Subfield: Health informatics
Published 2016-10-11
Even Fyllingen
Anne Line Stensjøen
Erik Magnus Berntsen
Ole Solheim
Ingerid Reinertsen
Dataset (501.23 MB)
To facilitate a more widespread use of volumetric tumor segmentation in clinical studies, there is an urgent need for reliable, user-friendly segmentation software. The aim of this study was therefore to compare three different software packages for semi-automatic brain tumor segmentation of glioblastoma; namely BrainVoyagerTM QX, ITK-Snap and 3D Slicer, and to make data available for future reference. Pre-operative, contrast enhanced T1-weighted 1.5 or 3 Tesla Magnetic Resonance Imaging (MRI) scans were obtained in 20 consecutive patients who underwent surgery for glioblastoma. MRI scans were segmented twice in each software package by two investigators. Intra-rater, inter-rater and between-software agreement was compared by using differences of means with 95 % limits of agreement (LoA), Dice’s similarity coefficients (DSC) and Hausdorff distance (HD). Time expenditure of segmentations was measured using a stopwatch. Eighteen tumors were included in the analyses. Inter-rater agreement was highest for BrainVoyager with difference of means of 0.19 mL and 95 % LoA from -2.42 mL to 2.81 mL. Between-software agreement and 95 % LoA were very similar for the different software packages. Intra-rater, inter-rater and between-software DSC were ≥ 0.93 in all analyses. Time expenditure was approximately 41 min per segmentation in BrainVoyager, and 18 min per segmentation in both 3D Slicer and ITK-Snap. Our main findings were that there is a high agreement within and between the software packages in terms of small intra-rater, inter-rater and between-software differences of means and high Dice’s similarity coefficients. Time expenditure was highest for BrainVoyager, but all software packages were relatively time-consuming, which may limit usability in an everyday clinical setting.
Science publication
Published : URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164891, Citation: Glioblastoma Segmentation: Comparison of Three Different Software Packages Fyllingen EH, Stensjøen AL, Berntsen EM, Solheim O, Reinertsen I (2016) Glioblastoma Segmentation: Comparison of Three Different Software Packages. PLoS ONE 11(10): e0164891. doi: 10.1371/journal.pone.0164891 (primary)
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Ingerid Reinertsen
Ingerid Reinertsen
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